Humanizing Animal Models: A Key to Autoimmune Diabetes Treatment
نویسندگان
چکیده
منابع مشابه
Lessons on autoimmune diabetes from animal models.
T1DM (Type I diabetes mellitus) results from selective destruction of the insulin-producing beta-cells of the pancreas by the immune system, and is characterized by hyperglycaemia and vascular complications arising from suboptimal control of blood glucose levels. The discovery of animal models of T1DM in the late 1970s and early 1980s, particularly the NOD (non-obese diabetic) mouse and the BB ...
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The spontaneous autoimmune diabetes of the nonobese diabetic mouse and the BioBreeding diabetes-prone rat bears a striking similarity to human type 1 diabetes. For this reason it comes as a disappointment that interventions known to prevent the disease in the animal models proved ineffective in human trials. For an explanation I propose that, although the mechanism of beta-cell destruction is t...
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ژورنال
عنوان ژورنال: Science Translational Medicine
سال: 2011
ISSN: 1946-6234,1946-6242
DOI: 10.1126/scitranslmed.3002102